Are there other medication options besides hydrocortisone or dexamethasone for managing CAH at age 52?
Yes, there are some newer treatment options that might be worth discussing with your endocrinologist.
Crinecerfont (Crenessity) was approved at the end of 2024 for people 4 years and older with classic CAH. It works Show Full Answer
Are there other medication options besides hydrocortisone or dexamethasone for managing CAH at age 52?
Yes, there are some newer treatment options that might be worth discussing with your endocrinologist.
Crinecerfont (Crenessity) was approved at the end of 2024 for people 4 years and older with classic CAH. It works differently than traditional glucocorticoids by targeting hormone pathways to reduce androgen levels. This may allow for lower doses of glucocorticoids.
Other medications being studied include:
* Modified-release hydrocortisone formulations that release slowly throughout the day to better mimic natural hormone rhythms
* Continuous subcutaneous hydrocortisone infusion delivered through a small pump under the skin
* ACTH receptor antagonists like atumelnant
* ACTH antibodies
Some of these newer approaches have shown promise in controlling androgen levels while potentially reducing side effects like bone loss. However, more research is needed to fully understand long-term benefits and risks.
Given your years on glucocorticoid therapy, it would be helpful to talk with your healthcare team about whether any of these newer options might be appropriate for your situation. They can help weigh the potential benefits against any risks based on your individual health history.
November 22, 2025
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